Results 1 to 14 of 14

Thread: Disease and pandemics thread (because it's science)

  1. #1
    Join Date
    Sep 2004
    Location
    South Carolina
    Posts
    1,431

    Unhappy Disease and pandemics thread (because it's science)

    Speaking of eradicating Zika... now we can't. There's also a Zika epidemic going on in India right now, started less than a month ago.


    https://www.sciencedaily.com/release...1101133830.htm

    Zika circulates among wild animals in the Americas, making eradication nearly impossible

    November 1, 2018; University of Texas Medical Branch at Galveston

    Researchers report that wild monkeys in the Americas are transmitting the Zika virus to humans via mosquitoes, making complete eradication of the virus in the Americas very unlikely. A collaborative group of researchers from The University of Texas Medical Branch at Galveston and the Faculty of Medicine of Sao Jose do Rio in Brazil is the first to report that wild monkeys in the Americas are transmitting the Zika virus to humans via mosquitoes, making complete eradication of the virus in the Americas very unlikely. The paper is currently available in Scientific Reports.

    "Our findings are important because they change our understanding of the ecology and transmission of Zika virus in the Americas," said senior author Nikos Vasilakis, UTMB professor in the department of pathology. "The possibility of a natural transmission cycle involving local mosquitoes and wild local primates as a reservoir and amplification host will definitely impact our predictions of new outbreaks in the Americas, because we cannot eradicate this natural transmission cycle." Vasilakis said that as yellow fever has shown, disease outbreaks among animals will always be a source of epidemics in humans, even after a possible control and suppression of urban transmission through vaccination and treatments is established.
    There is something fascinating about science. One gets such wholesale returns of conjecture out of such a trifling investment of fact.
    Mark Twain, Life on the Mississippi (1883)

  2. #2
    Join Date
    Feb 2006
    Posts
    500
    In other words, vaccination is very important.
    Selden

  3. #3
    Join Date
    Sep 2004
    Location
    South Carolina
    Posts
    1,431
    A vaccine for Zika is in development, hope for the best.

    https://www.pbs.org/newshour/science...ppened-to-zika
    PBS article on the state of Zika research, from July. Hurricane Maria destroyed many mosquitoes in Puerto Rico, slowing the outbreak there.
    There is something fascinating about science. One gets such wholesale returns of conjecture out of such a trifling investment of fact.
    Mark Twain, Life on the Mississippi (1883)

  4. #4
    Join Date
    Jan 2010
    Location
    Wisconsin USA
    Posts
    2,656
    The power of microbiology is one of the greatest powers in the universe. Far outstripping humans. Some bacteria and viruses can replicate every 20 minutes. Given enough food, travel ability, and sanitation they would be able to produce the whole mass of the universe, with their kind, in less than a week.
    The moment an instant lasted forever, we were destined for the leading edge of eternity.

  5. #5
    Join Date
    Sep 2004
    Location
    South Carolina
    Posts
    1,431
    Superbugs: killing you better every year!


    https://medicalxpress.com/news/2018-...-annually.html

    Antibiotic-resistant bacteria now claiming 33,000 lives annually

    November 7, 2018, European Centre for Disease Prevention and Control (ECDC)

    An ECDC study estimates the burden of five types of infections caused by antibiotic-resistant bacteria of public health concern in the European Union and in the European Economic Area (EU/EEA). The burden of disease is measured in number of cases, attributable deaths and disability-adjusted life years (DALYs). These estimates are based on data from the European Antimicrobial Resistance Surveillance Network (EARS-Net) data from 2015.

    The authors said, "The estimated burden of infections with antibiotic-resistant bacteria in the EU/EEA is substantial compared to that of other infectious diseases, and increased since 2007. Strategies to prevent and control antibiotic-resistant bacteria require coordination at EU/EEA and global level. However, our study showed that the contribution of various antibiotic-resistant bacteria to the overall burden varies greatly between countries, thus highlighting the need for prevention and control strategies tailored to the need of each EU/EEA country."

    The study estimates that about 33,000 people die each year as a direct consequence of an infection due to bacteria resistant to antibiotics and that the burden of these infections is comparable to that of influenza, tuberculosis and HIV/AIDS combined. It also explains that 75 percent of the burden of disease is due to healthcare-associated infections (HAIs) and that reducing this through adequate infection prevention and control measures, as well as antibiotic stewardship, could be an achievable goal in healthcare settings.

    Finally, the study shows that 39 percent of the burden is caused by infections with bacteria resistant to last-line antibiotics such as carbapenems and colistin. This is an increase from 2007, and is worrying because these antibiotics are the last treatment options available. When these are no longer effective, it is extremely difficult or, in many cases, impossible to treat infections.
    There is something fascinating about science. One gets such wholesale returns of conjecture out of such a trifling investment of fact.
    Mark Twain, Life on the Mississippi (1883)

  6. #6
    Join Date
    Sep 2004
    Location
    South Carolina
    Posts
    1,431
    We're screwed.

    https://medicalxpress.com/news/2018-...-outbreak.html

    The Congo Ebola outbreak might be uncontainable. Very short article, see other sources in links.
    There is something fascinating about science. One gets such wholesale returns of conjecture out of such a trifling investment of fact.
    Mark Twain, Life on the Mississippi (1883)

  7. #7
    Join Date
    Apr 2007
    Location
    Nowhere (middle)
    Posts
    35,536
    Quote Originally Posted by Roger E. Moore View Post
    We're screwed.

    https://medicalxpress.com/news/2018-...-outbreak.html

    The Congo Ebola outbreak might be uncontainable. Very short article, see other sources in links.
    But we already know that with proper treatment, Ebola is survivable. Just that the hot zones are usually in areas without proper treatment.
    "I'm planning to live forever. So far, that's working perfectly." Steven Wright

  8. 2018-Nov-07, 04:37 PM
    Reason
    Duplicate post

  9. #8
    Join Date
    Jul 2005
    Posts
    16,792
    There are people close to the outbreak who are in trouble, certainly. Beyond that, we're not remotely screwed.
    This thread's title suggests we should concentrate on the science.

    Grant Hutchison
    Blog

    Note:
    During life, we all develop attitudes and strategies to make our interactions with others more pleasant and useful. If I mention mine here, those comments can apply only to myself, my experiences and my situation. Such remarks cannot and should not be construed as dismissing, denigrating, devaluing or criticizing any different attitudes and strategies that other people have evolved as a result of their different situation and different experiences.

  10. #9
    Join Date
    Sep 2004
    Location
    South Carolina
    Posts
    1,431
    https://www.washingtonpost.com/healt...=.dc26ba0aee10

    Disaster looms in the Congo

    Between the war, public refusal to seek aid, and the deadliness of the virus -- and the inability of anyone to fully stamp the virus out -- things are looking grim for the Congolese province of 6 million. "...officials from the World Health Organization and other experts say one of the biggest worries is the spread within Congo to places like Butembo, a major trading port and urban area, where the risk of widespread transmission escalates dramatically."
    Last edited by Roger E. Moore; 2018-Nov-07 at 09:11 PM. Reason: add info
    There is something fascinating about science. One gets such wholesale returns of conjecture out of such a trifling investment of fact.
    Mark Twain, Life on the Mississippi (1883)

  11. #10
    Join Date
    Jul 2005
    Posts
    16,792
    Quote Originally Posted by Roger E. Moore View Post
    Paywall.
    Chasing the story around the internet, it seems that Robert Redfield (the CDC director) suggested that, if conflict in North Kivu continues to limit healthcare access to the area, there's a possibility Ebola could become endemic in that region.

    Grant Hutchison
    Blog

    Note:
    During life, we all develop attitudes and strategies to make our interactions with others more pleasant and useful. If I mention mine here, those comments can apply only to myself, my experiences and my situation. Such remarks cannot and should not be construed as dismissing, denigrating, devaluing or criticizing any different attitudes and strategies that other people have evolved as a result of their different situation and different experiences.

  12. #11
    Join Date
    Sep 2004
    Location
    South Carolina
    Posts
    1,431
    Update on the situation in Uganda.

    https://news.un.org/en/story/2018/11/1025101

    Frontline workers vaccinated in Uganda over Ebola fears, as top UN officials visit outbreak epicentre in DR Congo
    7 November 2018, Health

    The World Health Organization (WHO), and Ugandan Ministry of Health, have begun vaccinating frontline health workers in the country against Ebola, in a bid to stop an outbreak in the neighbouring Democratic of Congo (DRC) from crossing the border. The exercise, which began on Tuesday, is centred around five high-risk districts of Uganda that border the DRC (Bundibugyo, Kabarole, Kasese, Ntoroko and Bunyangabu) and involves the administering of 2,100 doses of vaccine to health workers, protecting them against the particular strain of Ebola currently circulating in some parts of DRC.

    No cases of Ebola have so far been reported in Uganda, but the authorities are implementing the plan in order to avoid the fatal consequences of previous outbreaks, which saw health workers contract the disease and die as they cared for patients. WHO said in a statement released on Wednesday that it is “highly likely” that Ugandans in districts near the border will be infected with the virus, due to their close proximity to the epicentre of the outbreak, and high population movements due to trade, social and cultural connections and the relatively easy access to health services.
    There is something fascinating about science. One gets such wholesale returns of conjecture out of such a trifling investment of fact.
    Mark Twain, Life on the Mississippi (1883)

  13. #12
    Join Date
    Sep 2004
    Location
    South Carolina
    Posts
    1,431
    This had better work.


    https://medicalxpress.com/news/2018-...eclinical.html

    Synthetic DNA-delivered antibodies protect against Ebola in preclinical studies
    November 13, 2018, The Wistar Institute

    Scientists at The Wistar Institute and collaborators have successfully engineered novel DNA-encoded monoclonal antibodies (DMAbs) targeting Zaire Ebolavirus that were effective in preclinical models. Study results, published online in Cell Reports, showed that DMAbs were expressed over a wide window of time and offered complete and long-term protection against lethal virus challenges. DMAbs may also provide a novel powerful platform for rapid screening of monoclonal antibodies enhancing preclinical development.

    Ebola virus infection causes a devastating disease, known as Ebola virus disease, for which no licensed vaccine or treatment are available. The 2014-2016 Zaire Ebola virus epidemic in West Africa was the most severe reported to date, with more than 28,600 cases and 11,325 deaths according to the Center for Disease Control. A new outbreak is ongoing in the Democratic Republic of Congo, with a death toll of more than 200 people since August. One of the experimental avenues scientists are pursuing is evaluating the safety and efficacy of monoclonal antibodies isolated from survivors as promising candidates for further development as therapeutics against Ebola virus infection. However, this approach requires high doses and repeated administration of recombinant monoclonal antibodies that are complex and expensive to manufacture, so meeting the global demand while keeping the cost affordable is challenging.
    There is something fascinating about science. One gets such wholesale returns of conjecture out of such a trifling investment of fact.
    Mark Twain, Life on the Mississippi (1883)

  14. #13
    Join Date
    Jul 2005
    Posts
    16,792
    That's all a bit misleading.
    See your previous post - a vaccine is available, and is in use despite still working its way through the complex licencing requirements.
    And of course treatment is available, too, with a significant success rate - but unfortunately difficult-to-impossible to deliver in rural Africa during a civil war.

    Grant Hutchison
    Blog

    Note:
    During life, we all develop attitudes and strategies to make our interactions with others more pleasant and useful. If I mention mine here, those comments can apply only to myself, my experiences and my situation. Such remarks cannot and should not be construed as dismissing, denigrating, devaluing or criticizing any different attitudes and strategies that other people have evolved as a result of their different situation and different experiences.

  15. #14
    Join Date
    Apr 2007
    Location
    Nowhere (middle)
    Posts
    35,536
    With modern medicine available, Ebola is just another nasty hemorrhagic disease. Not a universal Omniphage. Like Bubonic Plague is no longer a plague. It's containable.
    "I'm planning to live forever. So far, that's working perfectly." Steven Wright

Tags for this Thread

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •