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Noclevername
2014-Feb-04, 11:19 PM
Stimulus triggered acquisition of pluripotency cell (http://en.wikipedia.org/wiki/Stimulus-triggered_acquisition_of_pluripotency_cell)


Stimulus-triggered acquisition of pluripotency cells (also known as STAP cells) are a type of pluripotent stem cell that can be generated by subjecting ordinary cells to certain types of stress, such as the application of a bacterial toxin, submersion in a weak acid, or physical squeezing.[1][2]

In the original research presenting the technique, STAP cells were produced by bathing differentiated T cells in an acid bath with a pH of 5.7 for half an hour. Following this treatment, the cells were verified to be pluripotent after observing Oct-4, a transcription factor expressed in embryonic stem cells, using green fluorescent protein.[3] On average, 25% of cells survive the stress and 30% of those that survive convert to pluripotent cells.[1] Squeezing the cells had an effect, but with lower efficiency. STAP cells injected into mouse embryos grew into a variety of tissue and organs found throughout the body. According to the researchers, the mice "[appeared] to be healthy, fertile, and normal" after one to two years of observation.[4]

STAP cells are able to differentiate into placental cells, meaning they are more potent than embryonic stem cells or induced pluripotent stem cells (iPS).[1] It is not clear why ordinary cells do not convert to stem cells when subjected to stimuli such as acid in the body. It is hypothesized that the reaction is somehow blocked when the cells are within a body. Work is underway to generate stimulus-triggered acquisition of pluripotency cells using human tissue, but no results are available as of February 2014.[4]

Copernicus
2014-Feb-04, 11:28 PM
Stimulus triggered acquisition of pluripotency cell (http://en.wikipedia.org/wiki/Stimulus-triggered_acquisition_of_pluripotency_cell)

If there was a like button I would press it. So many applications for this to prevent disability.

Jens
2014-Feb-05, 04:03 AM
If there was a like button I would press it. So many applications for this to prevent disability.

These experiments were done in mice, and they're currently doing them with primate cells, so we just have to hope that this ends up working in human cells as well.