View Full Version : Holy Crap! A Vaccine Against Radiation!

2006-Jun-04, 01:05 AM
There's a lot of implications for this. (http://today.reuters.com/news/NewsArticle.aspx?type=scienceNews&storyID=2006-06-03T220500Z_01_N03212178_RTRUKOC_0_US-SCIENCE-GENETHERAPY.xml&pageNumber=1&imageid=&cap=&sz=13&WTModLoc=NewsArt-C1-ArticlePage1)
A second University of Pittsburgh team used gene therapy to deliver a compound called manganese superoxide dismutase-plasmid liposome (MnSOD-PL) to mice, and then exposed them to radiation.

The compound is known to protect cells from the effects of radiation. Dr. Joel Greenberger, a cancer specialist who led the study, has been trying to find effective ways to get the compound into vulnerable cells in the body.

Untreated mice irradiated at higher doses lost weight and died fairly rapidly due to bone marrow damage. But mice treated with the gene therapy lost no weight, had little bone-marrow damage, and lived longer, the researchers told the meeting.The focus of the treatments is for protecting people who might have been exposed to the effects of a "dirty bomb" set off by terrorists. I can't help but think that this would be a boon for astronauts, since they can get exposed to high levels of radiation while in space.

A related story is this. (http://www.medicalnewstoday.com/medicalnews.php?newsid=44392)
Studies utilizing a mouse model of lethal whole body gamma irradiation suggest that Radilex might have possible applications for treatment of neutropenia and anemia following radiation exposure. In a preliminary experiment performed at Oak Ridge National Laboratory, Tennessee, animals exposed to lethal radiation (6 Gray to 8 Gray) but which survived following Radilex treatment apparently had higher levels of the infection-fighting white blood cells and higher levels of oxygen-carrying red blood cells than did animals that were not treated with Radilex and that died after radiation exposure.

2006-Jun-04, 06:37 AM
Very nice!

2006-Jun-04, 08:30 AM
I wonder how well it works for heavy ions?


2006-Jun-05, 11:59 AM
I imagine this is here rather than in general science because you're thinking it could be used to protect astronauts from unpredictable solar radiation during interplanetary missions?

2006-Jun-28, 06:18 PM
The writers at SCI-AM must be disappointed. They will have to bash VSE another way.

2006-Jun-28, 06:22 PM
Define "lived longer". Did they not suffer radiation sickness? Milder sickness? Did they recover from it and die from something else or did it get them in the end anyway?

If I get baked, I'm not sure a prolonged battle with the effects of intense irradiation are exactly something I want to live with, even in a mild form.

The Supreme Canuck
2006-Jun-28, 06:29 PM
Now, are we talking protection from radiation sickness, cancer, or both?